Additional Staff Exchange – 2023
Stay in the University of Maribor, Slovenia
This stay in Slovenia is a part of the DOKI project (Diabetes, Kidney and Obesity). The pathogenesis of obesity and Type 2 Diabetes Mellitus (T2DM) is complex and multifactorial. Patients with T2DM present higher risk to develop severe complications and organ damage specially in the kidneys, heart, circulatory system and brain. One of the most common of these complications is the develop of chronic kidney disease with changes in glomerular hemodynamics, oxidative stress, inflammation, interstitial fibrosis and tubular atrophy. Thus, understand the pathogenesis of T2DM is crucial to prevent and treat the disease. To do this is necessary the use of animal models of obesity, metabolic syndrome and diabetes. Current animal models are mostly genotypic and monogenic and none of them reflect accurately the complex pathophysiology of T2DM. Furthermore, none of them develop the damage in kidney, heart, circulatory system and brain related to diabetes. Thus, the main objective of this stay was the development and the study of a model of T2DM accelerated by Tacrolimus with organ damage, specifically in the kidney.
The stay had a duration of 1 month, from September 30, 2023 to October 30, 2023. This stay was performed in the research group of Dr. Andraz Stozer and in the research group of Dr. Sbastjan Bevc, both in the University of Maribor, Slovenia.
Dates: September 30 to October 30, 2023
Place: University of Maribor, Slovenia
